The goalkeeper makes his first appearance since sustaining a calf injury during the opening-day victory over Norwich City on August 9.
Joel Matip also returns in defence; however, the Reds are without Mohamed Salah due to the ankle injury he picked up against Leicester City prior to the international break.
Divock Origi replaces him in the starting line-up at Old Trafford.
Liverpool: Alisson, Alexander-Arnold, Matip, Van Dijk, Robertson, Fabinho, Henderson, Wijnaldum, Mane, Origi, Firmino.
Subs: Adrian, Lovren, Milner, Keita, Gomez, Oxlade-Chamberlain, Lallana.