The forward scored three goals and claimed one assist to help Liverpool to victories in all four of their league outings during the month.
Mane began November by scoring a dramatic 94th-minute winner at Aston Villa, just moments after teeing up Andy Robertson for the Reds’ equaliser in the 2-1 success.
He was also on target in the victories over Manchester City and Crystal Palace as Jürgen Klopp’s side ended the month eight points clear at the division’s summit.
The 27-year-old has won the prize on two previous occasions – August 2017 and March 2019.
Mane faces competition from Dele Alli and Son Heung-min (Tottenham Hotspur), Raul Jimenez (Wolverhampton Wanderers), Lys Mousset (Sheffield United) and Caglar Soyuncu and Jamie Vardy (Leicester City) this time around.