The No.10 can become just the 18th player in history to net 100 goals for the Reds in all competitions.
Should Mane find the back of the net against AC Milan, he will join Michael Owen in joint-third place on the European scorers chart with 22 goals – with only Steven Gerrard and Mohamed Salah above them.
Read on for more facts and figures ahead of tonight's Champions League encounter...
Mohamed Salah's next appearance will be his 100th for Liverpool at Anfield, having scored 71 times in his previous 99.
If the Egyptian scores twice, he will move into outright second place on the Reds' all-time list of European scorers at Anfield – he currently has 13, with Ian Rush on 14 and Gerrard on 24.