The Indianapolis Colts have a very good chance of moving to 3-0 even if the Tennessee Titans were fully healthy, but Tennessee isn't. Not that any NFL game can be guaranteed, of course, but Indy is in prime position to be undefeated before the schedule gets a lot tougher.
Plus, while Tennessee is hosting the game in Nashville, the weather might actually be a disadvantage for them even while playing a team who players their own home games inside. Players need to stay fresh during games not to get worn out late in the game, but that likely will happen to the Titans.