James Rodriguez is out of table-topping Everton's trip to Southampton on Sunday.
Toffees manager Carlo Ancelotti revealed on Thursday that the Colombian superstar suffered an unspecified injury after a mistimed tackle from Virgil van Dijk.
Liverpool's talismanic centre-back lasted only 10 minutes of the Merseyside derby himself before he suffered an ACL injury in a rash challenge from Jordan Pickford.
The Everton goalkeeper's tackle on Van Dijk, and VAR's failure to check whether it was a red-card offence, has dominated the fallout from the 2-2 draw that kept Everton at the top of the Premier League after five games.