Manchester United need to bounce back from last Sunday's 4-0 embarrassment at Chelsea when Burnley come to Old Trafford this Saturday.
Jose Mourinho's men managed to get back on track after beating Manchester City in the EFL Cup in midweek but they have won just once in the league since Aug. 27.
City, meanwhile, are in trouble. Pep Guardiola travels to West Brom having not won in six matches. Elsewhere, last season's two title rivals Leicester and Tottenham face each other, Sunderland host Arsenal and Liverpool travel to Crystal Palace.
Predict the results of all Premier League matches this weekend in our match polls.