Crystal Palace are without forward Connor Wickham, who is set to miss the rest of the season after suffering anterior cruciate ligament damage.
Goalkeeper Steve Mandanda is out for up to six weeks following knee surgery, while midfielder Yohan Cabaye is banned after accumulating five yellow cards.
Dusan Tadic remains out for Southampton with a broken nose, while Matt Targett is sidelined by a hamstring problem.
Saints are set to recall captain Jose Fonte and top scorer Charlie Austin.
The pair were rested in Wednesday's EFL Cup win away to Arsenal.
MOTD COMMENTATOR'S NOTES
Mark Scott: "It's not just the damning statistics, but also Palace continuing to make the same mistakes that has put Alan Pardew's position under severe scrutiny.