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DeAngelo Williams is the latest Steelers' weapon out for Patriots game

PITTSBURGH -- The Pittsburgh Steelers will roll with Fitz Toussaint as their No. 2 running back in Sunday's game with the New England Patriots.

DeAngelo Williams will miss the game with a knee injury.

Williams, the NFL's leading rusher through the season's first two weeks while replacing the suspended Le'Veon Bell, tweaked the knee last week against Miami and didn't practice much this week. Williams has 275 yards and three rushing touchdowns on 74 carries, eight of which came in the past three weeks.

The Steelers also have practice squad tailbacks Daryl Richardson and Karlos Williams, but both players said they weren't sure whether they'd get called up to the 53-man roster.