It's early and with the game about three weeks away, the line could fluctuate. But for now, the Panthers look to be the early favorite.
One line has the Panthers as three-point favorites. Thanks to one of the readers in the comments section who mentioned this.
Frankly, I expected a bigger line. Pitt was nearly a 25-point favorite against Syracuse and big favorites against Duke the week before. While Northwestern is better than those teams, how much better is what I'd ask? For example, is Northwestern really 21 points better than Syracuse? Obviously the line goes by head to head matchups, so perhaps Vegas just thinks the WIldcats match up better than those teams because of their passing attack.