USA Track Track & Field has awarded the 2020 Olympic Trials to Mount San Antonio College in suburban Los Angeles.
Eugene had played host to the Olympic Trials in 2008, 2012 and 2016, and had bid for them again for 2020.
Steve Miller, chairman of USATF board directors, said track and field's governing body wanted to bring the trials to the country's second-largest media market.
"The board was presented with three excellent options for the 2020 Olympic Trials," Miller said in a statement. "The board, and especially our active athletes, were clear in their desire to take the Olympic Trials back to Los Angeles.