The Jackrabbits used an early 12-2 run to grab a 14-5 lead at the end of the first quarter.
After the Panthers tied the game with a 9-0 run of their own to start the second, SDSU proceeded to score the next 11 points.
UNI was able to cut the deficit to six at the half, but another big surge out of the locker room, this one 10-0, essentially put the game away for SDSU.
The Panthers shot just 18-of-53 from the field on the night, and Coach Tanya Warren said those offensive struggles were the biggest reason for the numerous SDSU runs.