Pablo Sandoval left the Boston Red Sox's game against the Baltimore Orioles with a right knee sprain, the Boston Globe's Pete Abraham reported.
The veteran third baseman is considered day-to-day. The Red Sox have Monday off before returning home for a three-game series with the New York Yankees.
Boston could potentially take on its heated rival without two starting infielders. In addition to Sandoval's injury, Abraham reported Dustin Pedroia will have an MRI Monday to determine the extent of the damage to his left ankle and knee after getting hurt in Friday's 2-0 defeat.