Chris Kendrix hit a pair of free throws to tie the game for the Bears with 16 seconds in the game after they blew a 13 point second half lead.
DePaul senior guard Billy Garrett Jr. responded with a buzzer beater to hand the Bears their first loss of the season.
After three easy wins for the Missouri State Bears, they faced their first test of the season in a 68-66 loss to the Big East’s DePaul Blue Demons.
“I thought we gave great effort,” head coach Paul Lusk said. “(I was) disappointed because I thought we outplayed them for most of the game.