James Shields suffered the defeat, despite working seven innings. The Twins got to him for two in the fourth after he retired the first nine, two in the fifth and one in the seventh. Shields finished the season with 19 losses between stops in San Diego and Chicago and with a 4-12 mark in 22 starts for the White Sox, striking out seven and walking three in his final trip to the mound this season.
Byron Buxton and Jorge Polanco delivered two-run blasts in support of Santiago. Buxton also scored from first with two outs in the seventh on Juan Centeno's double and did the same with two outs in the ninth.