Jose Mourinho and Pep Guardiola will oversee the first ever Manchester derby played on foreign soil at the NRG Stadium in Houston.
City and United saw last summer's friendly called off in farcical circumstances over in China but will finally lock horns abroad.
Here, Sportsmail looks at what sort of shape the two sides are in ahead of kick-off in the early hours of Friday morning.
How has pre-season gone so far?
This is City's first friendly but United have been stationed in the States for a week with two games already under their belt.