It's the Foxes' first game without Claudio Ranieri and there will be plenty of nerves in the team, with their 4-1 defeat to the Reds back in September also likely to be on the players' minds.
Liverpool got back to winning ways in their last domestic outing, confidently dispatching two without reply against top four rivals Tottenham Hotspur, thanks to a brace from one of the signings of the season, Sadio Mane.
So will Jurgen Klopp remain loyal to the same starting line-up that brushed aside Spurs?