The England international has not travelled to the King Power stadium with the rest of the squad as a result of a badly bruised foot.
Henderson picked up the injury in training last week and the Reds had hoped it would settle down in time for the game against the champions after initial concerns that the 26-year-old had broken his foot were allayed.
The bruising is thought to be severe enough for Jurgen Klopp’s staff to believe he could miss Saturday’s game with Arsenal as well – a clash crucial to their hopes of qualifying for the Champions League next season.