In their absence, Yost will get to see several young catchers, such as Cam Gallagher, Parker Morin, Zane Evans and Chase Vallot, as well as veteran Brayan Pena, a non-roster invitee.
Prospects Hunter Dozier and Ryan O'Hearn will get looks at first base while Hosmer is away.
"Our young catchers wouldn't have an opportunity to play very much, because we'd be trying to get Drew [Butera] ready and Sal [Perez] ready," Yost said. "So we get to see our young first basemen and then see our younger shortstops like [Ramon] Torres and [Humberto] Arteaga.