The last time the Colts and Titan met was in Week 17 of 2015 with both starting (and in the Colts case backup) quarterbacks out. It was not a game worth watching or remembering and I’m sorry for bringing it up.
Prior to that, the two met in Week 3 of 2015, the last appearance of Andrew Luck for a few weeks after suffering a shoulder injury. That game featured an epic fourth quarter rally with the Colts scoring 21 points in the final frame to eek out a two-point win. At the time, it was thought to be a season saving win.