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Notre Dame Fighting Irish vs. Syracuse Orange Betting Odds, Football Pick

Since playing in the national championship game four seasons ago, Notre Dame is just 18-15 straight up against major-conference competition. Some might argue otherwise, but Syracuse qualifies as a major-conference team. How will the Irish fare when they roll with the Orange on Saturday afternoon on a neutral field at MetLife Stadium in New Jersey?

Point spread: The Fighting Irish opened as 12-point favorites, according to sportsbooks monitored by Odds Shark (line updates and matchup report).

College football pick, via Odds Shark computer: 37.6-10.7, Fighting Irish (college football picks on every game)

Why the Notre Dame Fighting Irish can cover the spread

Notre Dame is looking to regroup following two straight home losses.