Everton's Under-23 side were crowned Premier League 2 champions after earning a favour from rivals Liverpool who beat second-placed Manchester City 3-2.
City needed to win their last two matches to have a chance of catching the Toffees.
However, their challenge ended when Reds midfielder Matty Virtue scored an added-time winner in their game at Tranmere's Prenton Park.
That match will see them meet rivals Liverpool at Goodison Park on May 8.
The championship is deserved reward for Unsworth's side, who have been beaten only three times in their 23 games this campaign.