The Tigers got a leadoff home run from Ian Kinsler, who sent an 0-2 pitch from Rays reliever-turned-starter Erasmo Ramirez over the wall near the foul pole in left field.
The Tigers have an early 1-0 lead.
Live blog: Tigers vs. Rays
The Tigers left Cleveland last weekend on a high, taking two of three from the defending American League champions.
What a difference a few days make.
The Tigers are turning to left-hander Daniel Norris to supply another solid start in hopes of avoiding a three-game sweep against the Rays on Thursday.