Full San Francisco 49ers Schedule & Opponents For The 2021 NFL Season

The 2021 San Francisco 49ers schedule has been released and San Francisco 49ers Report host Chase Senior breaks down every game in the 2021 NFL season for the San Francisco 49ers and head coach Kyle Shanahan. Jimmy Garoppolo enters his 5th season with the 49ers and Trey Lance is now on his tail as the new #3 overall pick. We take a look at all 17 49ers games this season, give instant schedule analysis, and tell you which games are played on Monday Night Football, Sunday Night Football, and Thursday Night Football.

San Francisco 49ers 2021 Schedule:
WEEK 1: at Detroit Lions
WEEK 2: at Philadelphia Eagles
WEEK 3: vs. Green Bay Packers (SNF)
WEEK 4: vs. Seattle Seahawks
WEEK 5: at Arizona Cardinals
WEEK 6: Bye
WEEK 7: vs. Indianapolis Colts (SNF) 
WEEK 8: at Chicago Bears
WEEK 9: vs. Arizona Cardinals
WEEK 10: vs. Los Angeles Rams (MNF)
WEEK 11: at Jacksonville Jaguars
WEEK 12: vs. Minnesota Vikings
WEEK 13: at Seattle Seahawks (SNF) 
WEEK 14: at Cincinnati Bengals
WEEK 15: vs Atlanta Falcons
WEEK 16: at Tennessee Titans (TNF)
WEEK 17: vs. Houston Texans
WEEK 18: at Los Angeles Rams

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