Right-hander Marco Estrada picked up the victory for Toronto after he allowed four runs (three earned) on five hits and two walks over six innings. The Blue Jays then turned things over to their new-look bullpen, as setup men Joaquin Benoit and Jason Grilli bridged the gap to closer Roberto Osuna.
Orioles right fielder Mark Trumbo had a two-run double in the loss while Manny Machado went 1-for-2 with a solo homer and three runs scored. Right-hander Kevin Gausman took the loss after he surrendered six runs on six hits and three walks over just three innings, which matched a season low previously set on June 15 at Boston.