Greinke (14-6) lasted just four innings, his shortest stint of the season, and as a result, the D-backs were forced to make a pair of roster moves following the game to try to get through Sunday's series finale.
Relievers J.J. Hoover and Silvino Bracho, both of whom were forced into action Saturday, were optioned to Triple-A Reno.
The D-backs are planning on starting reliever T.J. McFarland on Sunday, but he can throw a maximum of about 60 pitches, meaning there will be a number of innings that need to be covered.